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- Brand name: Viramune
- Active Ingeridents(Generic Name) : Nevirapine
- Company Name: Boehringer
- Package:60 Tablets/Bottle
- Strength : 200mg
This drug is used with other HIV medications to help control HIV infection. It helps to decrease the amount of HIV in your body so your immune system can work better. This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life. Viramune (Nevirapine) belongs to a class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Mechanism of action:
Viramune (Nevirapine) falls in the non-nucleoside reverse transcriptase inhibitor (NNRTI) class of antiretrovirals. Both nucleoside and non-nucleoside RTIs inhibit the same target, the reverse transcriptase enzyme, an essential viral enzyme which transcribes viral RNA into DNA. Unlike nucleoside RTIs, which bind at the enzyme's active site, NNRTIs bind allosterically at a distinct site away from the active site termed the NNRTI pocket.
Viramune (Nevirapine) is not effective against HIV-2, as the pocket of the HIV-2 reverse transcriptase has a different structure, which confers intrinsic resistance to the NNRTI class.
Resistance to Viramune (Nevirapine) develops rapidly if viral replication is not completely suppressed. The most common mutations observed after Viramune (Nevirapine) treatment are Y181C and K103N, which are also observed with other NNRTIs. As all NNRTIs bind within the same pocket, viral strains which are resistant to Viramune (Nevirapine) are usually also resistant to the other NNRTIs, efavirenz and delavirdine. However, second generation NNRTIs like rilpivirine and etravirine are effective in treatment for HIV strains resistant to Viramune (Nevirapine) and other first generation drugs in that same class.
Dosage and Administration:
Use Viramune (Nevirapine) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
· Viramune (Nevirapine) comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Viramune (Nevirapine) refilled.
· Take Viramune (Nevirapine) by mouth with or without food.
· Side effects:
Tiredness, nausea, vomiting, or diarrhea may occur. Drowsiness may rarely occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Before taking Viramune (Nevirapine), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems (such as hepatitis B or C, cirrhosis), kidney dialysis, lactose or galactose intolerance.
Store Viramune (Nevirapine) at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light.