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Brand name: Erlocip
Active Ingeridents(Generic Name) : Erlotinib
Company Name: Cipla
Package: 30 tabs
It is used to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. It is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR).
Mechanism of action:
Erlocip (Erlotinib) is an epidermal growth factor receptor inhibitor (EGFR inhibitor). The drug follows gefitinib, which was the first drug of this type. Erlocip (Erlotinib) specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase, which is highly expressed and occasionally mutated in various forms of cancer. It binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When Erlocip (Erlotinib) binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.
Dosage and Administration:
Use Erlocip (Erlotinib) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
· Take Erlocip (Erlotinib) by mouth with a glass of water on an empty stomach at least 1 hour before or 2 hours after eating.
· Wash your hands immediately after taking Erlocip (Erlotinib).
· Take Erlocip (Erlotinib) on a regular schedule to get the most benefit from it. Taking Erlocip (Erlotinib) at the same time each day will help you to remember to take it.
· If you miss a dose of Erlocip (Erlotinib), contact your doctor right away.
Important things to remember about the side effects of Erlocip (Erlotinib):
The following side effects are common (occurring in greater than 30%) for patients taking Erlocip (Erlotinib):
- Rash , Diarrhea, Poor appetite, Fatigue, Shortness of breath, Cough, Nausea and vomiting
These side effects are less common side effects (occurring in about 10-29%) of patients receiving Erlocip (Erlotinib):
- Infection, Mouth sores, Itching, Dry skin, Eye irritation, Abdominal pain
· Before starting Erlocip (Erlotinib) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Certain medications can interfere with the levels/effects of Erlocip (Erlotinib). It is important your oncologist is aware of all medications. Do not take aspirin, or products containing aspirin unless your doctor specifically permits this.
Store: Erlocip (Erlotinib) room temperature away from moisture and heat.