Duovir Zidovudine /Lamivudine

Indication:

Duovir (Zidovudine /Lamivudine) are antiviral medications that prevent human immunodeficiency virus (HIV) cells from multiplying in your body.

 Duovir (Zidovudine /Lamivudine) is a combination medicine used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). This medicine is not a cure for HIV or AID.

Mechanism of action:

Zidovudine:

Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). It inhibits the activity of HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleotide analogue. It competes with the natural substrate dGTP and incorporates itself into viral DNA. It is also a weak inhibitor of cellular DNA polymerase and .

Lamivudine:

Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination.

Dosage and Administration:

• Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
• Duovir (Zidovudine /Lamivudine) can be taken with or without food.
• HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.